A Cancer Stem Cell Potent Copper(II) Complex with a <i>S</i> , <i>N</i> , <i>S</i> ?Schiff base Ligand and Bathophenanthroline

نویسندگان

چکیده

We investigate the anti-cancer stem cell (CSC) properties of two copper(II) complexes containing 4,7-diphenyl-1,10-phenanthroline and a S, N, X-Schiff base ligand, where X=O (1) or S (2). Complex 1 was previously reported by us, is first metal complex to induce cytotoxic immunogenic death breast CSCs. 2 structural analogue 1, phenolate moiety (within Schiff ligand) replaced thiophenolate group. kills bulk cancer cells CSCs in sub-micromolar range, with reduced toxicity towards non-cancerous epithelial cells. Remarkably, over 10-fold more potent CSC spheroids than salinomycin (an established anti-breast agent) cisplatin (a clinically approved anticancer drug). readily enters CSCs, accumulates cytosol, increases intracellular reactive oxygen species (ROS) levels upon short exposure (1 h). The latter likely be mechanism which induces death.

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ژورنال

عنوان ژورنال: European Journal of Inorganic Chemistry

سال: 2021

ISSN: ['1434-1948', '1099-0682']

DOI: https://doi.org/10.1002/ejic.202100125